Dudediligence.

Spyre Therapeutics, Inc

SYRENASDAQ · Pharmaceutical Preparations
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Last 12 months

Sales planned on beside the trades reported on , and whether each names a .

Planned ·

$440.1M

17 notices · 5,176,739 sh

Mar 3 to Oct 4

Reported ·

$422.1M

45 sales · 0 buys

Oct 2025 to Jun 2026

The two figures cover different periods.

44 of 45 reported sales carry the 10b5-1 box. Together they are 5.74% of the shares on issue.

PLANNED · FORM 144Mar 3 to Oct 4REPORTED · FORM 4Oct 2025 to Jun 2026N2025DJ2026FMAMJJASO2026-10-01: CAMERON TURTLE, Form 1442026-10-01: HEIDY KING-JONES, Form 1442026-09-30: SCOTT BURROWS, Form 1442026-09-01: HEIDY KING-JONES, Form 1442026-08-07: JEFFREY ALBERS, Form 1442026-08-07: SESSIONS, LLC, Form 1442026-08-03: SCOTT BURROWS, Form 1442026-07-01: CAMERON TURTLE, Form 1442026-06-25: SCOTT BURROWS, Form 1442026-06-23: Fairmount Healthcare Fund II L.P., Form 1442026-06-22: MICHAEL HENDERSON, Form 1442026-06-03: SHELDON SLOAN, Form 1442026-05-08: MICHAEL HENDERSON, Form 1442026-05-01: SHELDON SLOAN, Form 1442026-05-01: SCOTT BURROWS, Form 1442026-04-01: SHELDON SLOAN, Form 1442026-03-03: SCOTT BURROWS, Form 1442025-11-03: Turtle Cameron, sold2025-12-01: Turtle Cameron, sold2026-01-02: Turtle Cameron, sold2026-02-02: Turtle Cameron, sold2026-03-02: Turtle Cameron, sold2026-03-03: Burrows Scott L, sold2026-04-01: Sloan Sheldon, sold2026-04-01: Turtle Cameron, sold2026-04-01: Burrows Scott L, sold2026-05-01: Turtle Cameron, sold2026-05-01: Burrows Scott L, sold2026-05-01: Sloan Sheldon, sold2026-05-08: HENDERSON MICHAEL THOMAS, sold2026-06-01: Burrows Scott L, sold2026-06-01: Turtle Cameron, sold2026-06-03: Sloan Sheldon, sold2026-06-22: HENDERSON MICHAEL THOMAS, sold2026-06-23: Harwin Peter Evan, sold
under a no plan named▼ salesize is dollars

Form 144 notices, newest first

2026-10-01CAMERON TURTLE, Chief Executive Officer$4,006,350
45,000 shplan 2025-06-20Form 4s on file end Jun 23144 ↗
2026-10-01HEIDY KING-JONES, See Remarks$2,611,695
29,335 shplan 2026-04-16Form 4s on file end Jun 23144 ↗
2026-09-30SCOTT BURROWS, Chief Financial Officer$1,573,157
17,500 shno plan dateForm 4s on file end Jun 23144 ↗
2026-09-01HEIDY KING-JONES, See Remarks$4,168,584
46,665 shplan 2026-04-16Form 4s on file end Jun 23144 ↗
2026-08-07JEFFREY ALBERS, Director$517,100
5,000 shplan 2026-04-16Form 4s on file end Jun 23144 ↗
2026-08-07SESSIONS, LLC, Director$1,861,560
18,000 shplan 2026-04-16Form 4s on file end Jun 23144 ↗
2026-08-03SCOTT BURROWS, Chief Financial Officer$2,949,900
30,000 shplan 2025-11-10Form 4s on file end Jun 23144 ↗
2026-07-01CAMERON TURTLE, Chief Executive Officer$3,995,100
45,000 shplan 2025-06-20Form 4s on file end Jun 23144 ↗
2026-06-25SCOTT BURROWS, Chief Financial Officer$1,306,980
15,000 shno plan date144 ↗
Form 4, 2026-06-26: sold 15,000 at $87.13 Form 4 ↗
2026-06-23Fairmount Healthcare Fund II L.P., Director$399.7M
4,684,781 shno plan date144 ↗
Form 4, 2026-06-23: sold 4,684,781 at $85.31 Form 4 ↗
2026-06-22MICHAEL HENDERSON, Director$1,766,800
20,000 shplan 2026-02-06144 ↗
Form 4, 2026-06-23: sold 20,000 at $100.00 Form 4 ↗
2026-06-03SHELDON SLOAN, Chief Medical Officer$1,152,690
16,667 shplan 2025-06-20144 ↗
Form 4, 2026-06-03: sold 8,333 at $75.00 Form 4 ↗
2026-05-08MICHAEL HENDERSON, Director$5,848,000
80,000 shplan 2026-02-06144 ↗
Form 4, 2026-05-08: sold 80,000 at $74.40 Form 4 ↗
2026-05-01SHELDON SLOAN, Chief Medical Officer$5,831,892
78,333 shplan 2025-06-20144 ↗
Form 4, 2026-05-01: sold 78,333 at $71.50 Form 4 ↗
2026-05-01SCOTT BURROWS, Chief Financial Officer$2,047,375
27,500 shplan 2025-11-10144 ↗
Form 4, 2026-05-01: sold 12,500 at $71.37 Form 4 ↗
2026-04-01SHELDON SLOAN, Chief Medical Officer$401,402
7,958 shplan 2025-06-20144 ↗
Form 4, 2026-04-03: sold 7,958 at $50.00 Form 4 ↗
2026-03-03SCOTT BURROWS, Chief Financial Officer$424,900
10,000 shplan 2025-11-10144 ↗
Form 4, 2026-03-03: sold 2,500 at $40.65 Form 4 ↗