Dudediligence.

Upstream Bio, Inc

UPBNASDAQ · Pharmaceutical Preparations
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Fundamentals

Oldest to newest
Revenue, by quarter
$607,000Sep ’24$613,000Dec ’24$566,000Mar ’25$937,000Jun ’25$683,000Sep ’25$668,000Dec ’25$1.0MMar ’26$773,000Jun ’26
Net income, by quarter
−$16.0MSep ’24−$21.2MDec ’24−$27.3MMar ’25−$40.0MJun ’25−$33.7MSep ’25−$42.5MDec ’25−$40.6MMar ’26−$39.7MJun ’26
Fiscal years, by the month each ended
LineDec 2023Dec 2024Dec 2025
Revenue$2.4M$2.4M$2.9M
Operating income−$40.1M−$77.8M−$160.4M
Net income−$20.5M−$62.8M−$143.4M
Operating cash flow−$37.9M−$59.2M−$133.3M
Free cash flow−$38.1M−$59.7M−$133.4M
Cash$25.8M$325.9M$101.6M
Shares outstanding3.0M53.6M54.2M